Myotonic dystrophy health index mdhi
WebMyotonic dystrophy type 1 (DM1) is known to affect cognitive function, but the best methods to assess CNS involvement in multicenter studies have not been determined. ... (PROs), including the Myotonic Dystrophy Health Index (MDHI) and EQ-5D-5L.Based on intra-class correlation coefficients (ICCs), computerized cognitive tests had moderate to ... WebJun 4, 2015 · Introduction: The Myotonic Dystrophy Health Index (MDHI) is a disease-specific patient-reported outcome measure. Here, we examine the associations between the MDHI and other measures of disease burden in a cohort of individuals with myotonic dystrophy type-1 (DM1). Methods: We conducted a cross-sectional study of 70 patients …
Myotonic dystrophy health index mdhi
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WebJul 20, 2011 · The Myotonic Dystrophy Health Index (MDHI) is a validated disease-specific measure of patient-reported disease burden. The MDHI total score is a weighted average derived from 17 subscales. MDHI total scores range form 0-100 with 0 representing no patient-reported disease burden and 100 representing the most severe patient-reported … WebJan 12, 2024 · Introduction: When preparing for clinical trials in myotonic dystrophy type-1 (DM1), it is important that researchers develop and identify patient-reported outcome measures with good measurement properties.Methods: Fifty-two DM1 patients enrolled in 2 clinical studies completed the Myotonic Dystrophy Health Index (MDHI), 36-Item Short …
WebMyotonic Dystrophy Foundation WebThe MDHI was the only score that was associated with participant employment status, CTG repeat length, and the 3 measurements of clinical function. Discussion: The MDHI …
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WebMyotonic muscular dystrophy is a common multi-system disorder that affects the skeletal muscles (the muscles that move the limbs and trunk) as well as smooth muscles (the …
WebApr 3, 2024 · and surveys, including the Myotonic Dystrophy Health Index,12 Association Francaise contre les Myopathies (AFM) DM1 survey,13 Naarden Myotonic Dystrophy Consensus data set,14 and the Myotonic Dystrophy Foundation’s patient regis-try. Others items were added on the basis of suggestions from the panel of experts, patients, and … neff t46fd53x2 currysWebMyotonic dystrophy type 2 (DM2) lacks validated patients´ reported outcomes (PROs). This represents a limit for monitoring disease progression and perceived efficacy of symptomatic treatments. Our aim was to investigate whether PROs for activities of daily living designed for other neuromuscular diseases could be used in DM2. neff t46fd53x2 best priceWebJan 25, 2024 · The Myotonic Dystrophy Health Index (MDHI) is a disease‐specific, patient‐reported outcome measure. The objective of this study was to translate, evaluate, … neff t46fd53x2 60cmWebJun 1, 2014 · DISCUSSION The Myotonic Dystrophy Health Index (MDHI) is a novel disease‐specific, multifaceted patient‐reported outcome measure for the most common adult muscular dystrophy. Designed for use in clinical trials, the MDHI estimates disease burden and is comprised of 17 subscales that measure the most important symptomatic … i thirst jesus last wordsWebFeb 27, 2024 · AM0-02 is a clinical stage investigational medicine for the treatment of the severe form of congenital myotonic dystrophy known as CDM1 or Steinert disease. AMO-02 has a dual mechanism disrupting the pathogenic RNA repeat in CDM1 and inhibiting excess levels of the kinase GSK3β. About AMO Pharma i thirst mother teresaWebThe degree of neuromuscular impairment can be clinically assessed using the muscle impairment rating scale (MIRS) rating scale while other rating scales such as the myotonic dystrophy health index (MDHI) and DM1-Activ assess the broader phenotype [9,10,11]. i thirst mark lowryWebApr 13, 2024 · Myotonic dystrophy (DM) is a type of muscular dystrophy, which is a group of genetic disorders. DM is the most common kind of muscular dystrophy in adults. … i thirst kjv