Dna pk inhibitor nu7441
WebNU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 … WebBiological Activity. NU 7441 is a potent and selective DNA-PK inhibitor (IC 50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. …
Dna pk inhibitor nu7441
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WebWO2024036156A1 PCT/CN2024/117405 CN2024117405W WO2024036156A1 WO 2024036156 A1 WO2024036156 A1 WO 2024036156A1 CN 2024117405 W CN2024117405 W CN 2024117405W WO 2024036156 A1 WO202 WebUsing HER2 positive mammary carcinoma cells, we investigated the impact of NU7441, a DNA-PK inhibitor, on irradiated monolayer and spheroid cultures. Colony formation assays were performed with monolayer culture cells and spheroids after irradiation with/without NU7441 (5 μM).
WebNU7441 caused doxorubicin- and IR-induced DNA DSBs (measured by γ-H2AX foci) to persist and also slightly decreased homologous recombination activity, as assessed by Rad51 foci. Chemo- and radio-potentiation were induced by NU7441 in M059-Fus-1, but not in DNA-PK-deficient M059 J cells. WebMay 15, 2006 · NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation …
WebMay 29, 2012 · ATM kinase inhibitor KU55933 and DNA-PK kinase inhibitor NU7441 were reconstituted in DMSO and used at 10 μM and 5 μM, respectively . I-PpoI was induced in TPC-1 cells infected with HA-ER-I-PpoI retrovirus by using 4-OHT for 6 h in the presence of vehicle, KU55933, or NU7441. WebNU 7441 is a potent and selective DNA-PK inhibitor (IC 50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects …
WebMay 23, 2011 · NU7441 was identified as a potent and specific ATP competitive inhibitor of DNA-PK (IC 50 14 nmol/L) with 100-fold selectivity for DNA-PK relative to other members of the PI3KK family. NU7441 increased the sensitivity of colon cancer cells to IR and topoisomerase II inhibitors, and altered their cell cycle profile.
WebKU60648 is a potent, dual inhibitor of DNA-PK and PI3K, inhibits DNA-PK and PI3Kα/β/δ with IC50 of 8.6 nM and 4/0.5/0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 uM. KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. ... raymond trainhamWebNU7441 is a selective inhibitor of DNA-dependent protein kinase (DNA-PK) with IC50 value of 13 nM [1]. NU7441 is an ATP-competitive inhibitor of DNA-PK and showed a Ki value of 0.65 nM. The inhibition of DNA-PK was selective. NU7441 showed no inhibition effect on the DNA-PK-related enzymes ATM and ATR at concentration of 100 μM. simplify definedWebNU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM). Targets&IC50. DNA-PK:13 nM (cell free) In vitro. 0.3 μM of KU-57788 (NU7441), nontoxic to both normal and tumor cells, caused a significant radio-sensitization in tumor cells exposed to X-rays and carbon ions. This concentration did not seem to cause ... raymond tracing actorWebAZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. CAS No. 2230820-11-6 Selleck's AZD7648 has been cited by 8 Publications Cancer Cell,2024S1535-6108 (21)00662-0 Cell,2024242 (3):685-712.e19 Mol Cell,202482-20:3932-3942.e6 Nat Commun,202413 … raymond trailray e 10WebDec 20, 2024 · Cells were treated with the DNA-PK inhibitor NU7441 (1 μM) for 3 h and were then treated with 100 nM CLM or DMSO (control) for 6 h in the presence of 1 μM NU7441 or DMSO (control). Arrowheads indicate G3BP1 positive cytosolic SGs with Venus-FUS WT or Venus-FUS mutant proteins. Scale bar: 20 μm. raymond train derailedWebJun 5, 2015 · The ATR inhibitor VE-821, ATM inhibitor KU55933 and DNA-PK inhibitor NU7441 were purchased from Tocris Bioscience (Bristol, UK). TRE-BCBL-1-RTA cells were treated with specified concentrations of kinase inhibitors, or equivalent DMSO control, 1 h prior to the addition of 0.5 μg/mL doxycycline. Cells were harvested after 24 and 48 h for … simplify derbyWebBAY-8400 (BAY8400) is a highly potent, selective inhibitor of DNA-PK with biochemical IC50 of 81 nM, cellular IC50 of 69 nM (γH2AX in HT-144). BAY-8400 showed good selectivity against PI3K and ATR, ATM and mTOR. In the KINOMEscan panel, >50% inhibition activity of BAY-8400 at 1 uM was measured only for three out of 365 kinases, … simplify delivery