Cisplatin target

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August undefined, 2024

WebSep 26, 2014 · Abstract The objectives of this study were to identify specific long noncoding RNAs (lncRNAs) in laryngeal squamous cell carcinoma (LSCC) and to clarify the function of cisplatin and paclitaxel on the confirmed laryngeal cancer lncRNAs. Fifty-four pairs of laryngeal tumor and adjacent normal tissue were collected. WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …

Reversal of resistance to cisplatin in NSCLC by miRNA-195-5p

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebOct 2, 2024 · Cisplatin is a platinum compound which is widely used in the treatment of various solid tumors including ovarian cancer. Up to now, the mechanism of cisplatin resistance in ovarian cancer is unclear. church of england christmas video

Targeted delivery of a cisplatin prodrug for safer and …

WebOct 31, 2024 · Here, we demonstrate that targeting PAPSS1 in conjunction with cisplatin treatment leads to better response rates in vivo. Clinically, we discovered that low PAPSS1 expression is associated with increased survival rates in chemotherapy-treated NSCLC and ovarian cancer patients. WebApr 13, 2024 · Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the … WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, … church of england church near me

Cisplatin-resistant A549 non-small cell lung cancer cells can be ...

Gene scissors find target for testicular cancer therapy

WebNov 11, 2008 · The ability of cis-diamminedichloroplatinum(II), cisplatin (9, 10), to inhibit the growth of cancer cells by interfering with transcription and other DNA-mediated cellular functions has been elucidated over the past 30 years.Cisplatin is highly effective against several forms of cancer, most notably testicular tumors, and it is also commonly used to … Web2 days ago · In addition to genes already known for cisplatin resistance, to our surprise we found the gene NAE1, the regulator of the neddylation cascade," says first author Kai Funke, a Ph.D. student of Prof ... dewalt power tool combo kit saleWebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin … church of england churchwardens handbook

"WebJan 6, 2024 · Cisplatin-related genes were downloaded from GeneWeaver. The protein-protein interaction (PPI) network was created using the STRING database. A drug-bioactive compound-disease-target network was constructed using Cytoscape. GO and KEGG analyses were performed to investigate common targets of quercetin and cisplatin in … " - Cisplatin target

Cisplatin target

Cisplatin (NSC 119875) ≥99%(HPLC) - selleckchem

WebThe drug can be administered to hemodialysis (HD) patients to achieve an AUC of 4–6 such that carboplatin dose (mg)=Target AUCx25. The drug is not avidly protein bound shortly after administration, and approximately 70% is cleared by HD if performed within several hours after in- fusion (15). WebJul 28, 2024 · Many of the most commonly prescribed chemotherapeutics, including platinum-based compounds such as cisplatin, target the characteristic genomic instability of tumors by directly damaging the DNA. Chemotherapies are designed to selectively target rapidly dividing cells, where they cause critical DNA damage and subsequent cell death …

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WebJul 28, 2024 · Many of the most commonly prescribed chemotherapeutics, including platinum-based compounds such as cisplatin, target the characteristic genomic instability of tumors by directly damaging the … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

WebCisplatin is a member of the alkylating agents drug class and is commonly used for Anal Cancer, Bladder Cancer, Blood Cell Transplantation, and others. ... , Target, WalMart … WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared.

WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … WebWe found that miR-195-5p might play a role as an oncogene in LC cells and have an inhibitory effect on chemotherapy resistance to cisplatin. Afterward, by target gene prediction and confirmation, it was concluded that miR-195-5p might directly target downstream gene FGF2 to affect the resistance to cisplatin and migration invasion …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

WebJan 26, 2024 · They are looking at the cellular mechanism by which cisplatin is taken up by the cells of the stria vascularis to find ways to block uptake, as well as identify drugs that … church of england church for saleWebMar 1, 2024 · GRP78 and its downstream target AKT are important in regulating cisplatin resistance in ER stress-tolerant human lung cancer cells [197]. Inhibition of GRP78 by siRNA sensitizes drug-resistant human melanoma cells to cisplatin- and doxorubicin-induced apoptosis [198] . church of england churchyard regulations 2022Web2 days ago · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells … church of england churchyard regulationsWebJan 10, 2024 · Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Authors church of england churchesWeb1 day ago · Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate cancer bearing C57BL/6 mouse model. (A) ... Antigen retrieval was completed by using Dako Target Retrieval Solution in low pH (pH 6.1) at 97 °C for 20 ... church of england churchwardenWebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other cancer … church of england churchwardensWebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, … church of england churchyards