WebFeb 16, 2024 · BPA can be transferred to rodent offspring through the placenta and in maternal milk, but quantities found are only a very small fraction of the amount … WebMay 6, 2024 · Purpose Serum and urinary bisphenol A (BPA) concentrations have been associated negatively with the number of retrieved oocytes after in vitro fertilization (IVF). The impact of BPA upon women with polycystic ovary syndrome (PCOS) and women with tubal factor infertility (TFI), following IVF, was investigated. To this purpose, associations …
In vivo and in vitro transcriptomics meta-analyses reveal …
WebBisphenol A (BPA) is an endocrine-disrupting chemical utilized in the manufacture of food packaging, dental materials, medical devices, children's toys, and baby products. Numerous studies have indicated the role of BPA in the etiology of many diseases such as diabetes, cardiovascular diseases, obesity, cancer, and chemotherapeutic resistance. WebSep 15, 2024 · We found that BPA may affect basic cellular processes, such as cell growth, survival, proliferation, differentiation, and apoptosis, independent of species and specific … tix toro
The Interplay Between TGF-β Signaling and Cell Metabolism
WebApr 18, 2024 · BPA, BPS, and BPAF all increased cell proliferation and gene expression including subtypes of collagen (COL1A1, COL15A1, and COL16A1) and regulators of fibrosis (TGFB, TGFBR, and SMAD). Compared to controls, fibrosis was more evident in spheroids treated with BPA, BPS, and BPAF for 7 days. WebAug 7, 2024 · Although the TGF-β ligand is inactivated by its association with the latency associated peptide (LAP) in the extracellular matrix (ECM) (Kaartinen and Warburton, 2003), many conditions, such as an acidic microenvironment, integrin interactions, or protein breakdown, can result in the release of TGF-β (Parvani et al., 2011 ). WebJun 6, 2024 · Bisphenol A (BPA) and its analogs are frequently detected in human daily necessities and environmental media. Placental thyroid hormone plays an important role in fetal development. Herein, we followed the adverse outcome pathway (AOP) to explore the toxic mechanisms of BPA and its analogs toward placental thyroid hormone receptor … tix tox logo